This manual is intended to provide an overview of key gender integration concepts and concrete guidance on how to integrate gender in improvement activities. The manual was written to guide HCI staff, but will be useful to anyone who wishes to address gender considerations in improvement work. The implementation guide includes key definitions and concepts of gender integration and how they relate to quality improvement, information on international agencies’ perspectives on gender, guidance on how to integrate gender into improvement activities and how, when, and why to conduct gender analysis. Next the guide provides a sampling of tools and indicators for the collection of data to inform gender integration, case studies from the field, reporting guidance and tips for staff to facilitate gender discussions. The manual includes a gender integration checklist available in four languages: English, French, Russian, and Spanish and a PowerPoint presentation on facilitating gender discussions.